Anxiety

Table of contents:

Description
Related genes
Clinical Features
Incidence and onset information
Alternative Names
Researches and researchers
Gene Panels
Sources and references

Description

Human personality is shaped by genetic and environmental factors, and evidence suggests that the genetic component is highly complex, polygenic, and epistatic. Genetic factors are thought to contribute to 40 to 60% of trait variance. Molecular genetics has tried to identify specific genes for quantitative traits, called quantitative trait loci (QTLs). The QTL concept suggests that complex personality traits or dimensions are not attributable to single genes, but to multiple interacting genes (Reif and Lesch, 2003).Fullerton et al. (2003) stated that psychologists were in agreement that the wide variation in human personalities can be explained by a small number of personality factors, including neuroticism (a measure of emotional stability), which manifests at one extreme as anxiety, depression, moodiness, low self-esteem, and diffidence. They cited a number of studies that had described a relationship between high scores on measures of neuroticism and major depressive disorder. They also noted that theoretical studies had suggested that large samples of randomly ascertained sibs could be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits.See also panic disorder (PAND1 ), which is a subtype of anxiety disorder.

Genes related to Anxiety

SLC6A4

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Clinical Features

Phenotypes and symptoms related to Anxiety

Depressivity
Anxiety
Shyness

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Anxiety Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Autism/Intellectual Disability/Multiple Anomalies. By Human Genetics Laboratory, Munroe-Meyer Institute University of Nebraska Medical Center (United States). BDNF, RPS6KA3, SCN1A, BRAF, SLC2A1, SLC6A4, SLC9A6, SMC1A, KDM5C, SOS1, CDKL5, TCF4, MED12, TSC1, TSC2, UBE3A, HDAC8, CNTNAP2, FOXP2, CACNA1C , (...) View the complete list with 69 more genes Panel complete gene list BDNF, RPS6KA3, SCN1A, BRAF, SLC2A1, SLC6A4, SLC9A6, SMC1A, KDM5C, SOS1, CDKL5, TCF4, MED12, TSC1, TSC2, UBE3A, HDAC8, CNTNAP2, FOXP2, CACNA1C, NSD1, PCDH19, NLGN4X, NLGN3, SHANK3, SHANK2, ZEB2, CASK, CBL, SHOC2, RAB39B, ARX, PHF6, ASPM, SPRED1, MBD5, CHD7, TUBA1A, VPS13B, CREBBP, EHMT1, SMC3, DCX, DHCR7, NIPBL, RPGRIP1L, DMD, ERCC6, ERCC8, FGD1, FGFR1, FGFR2, FGFR3, FMR1, FOLR1, FOXG1, FOXP1, GABRB3, HOXA1, HPRT1, HRAS, AP1S2, KRAS, L1CAM, MAP2K1, MAP2K2, MECP2, MEF2C, MET, MID1, MKKS, KMT2D, NF1, NHS, NRAS, NRXN1, OPHN1, PAFAH1B1, ATRX, AVPR1A, PNKP, PQBP1, PTCH1, PTEN, PTPN11, RAD21, RAF1, RAI1, RELN Specificity 2 % Genes 100 %
Autism Spectrum Disorders. By Asper Biogene Asper Biogene LLC (Estonia). RPL10, SCN1A, SCN2A, BRAF, SLC6A4, SLC6A8, CDKL5, MED12, TSC1, TSC2, UBE3A, HDAC8, CNTNAP2, FOXP2, CACNA1C, NSD1, PCDH19, NLGN4X, SHANK3, ZEB2 , (...) View the complete list with 32 more genes Panel complete gene list RPL10, SCN1A, SCN2A, BRAF, SLC6A4, SLC6A8, CDKL5, MED12, TSC1, TSC2, UBE3A, HDAC8, CNTNAP2, FOXP2, CACNA1C, NSD1, PCDH19, NLGN4X, SHANK3, ZEB2, ADNP, ARX, SETD2, CHD7, SLC9A9, ANKRD11, VPS13B, NTNG1, CREBBP, EHMT1, SMC3, PTCHD1, DHCR7, NIPBL, ADSL, EN2, FOXG1, FOXP1, HOXA1, HPRT1, MAGEL2, MECP2, MID1, NHS, NRXN1, PDE8B, AVPR1A, PQBP1, PTPN11, RAD21, RAI1, RELN Specificity 2 % Genes 100 %
Autism. By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases (Spain). RPL10, SLC25A12, SLC6A4, UBE3A, CNTNAP2, FOXP2, CACNA1C, CACNA1F, CACNA1H, PCDH19, NLGN4X, NLGN3, SHANK3, ARX, SLC9A9, CNTN4, PTCHD1, EN2, GABRA5, GABRB3 , (...) View the complete list with 8 more genes Panel complete gene list RPL10, SLC25A12, SLC6A4, UBE3A, CNTNAP2, FOXP2, CACNA1C, CACNA1F, CACNA1H, PCDH19, NLGN4X, NLGN3, SHANK3, ARX, SLC9A9, CNTN4, PTCHD1, EN2, GABRA5, GABRB3, GABRG3, HOXA1, LAMB1, MECP2, NRXN1, OXTR, PDE8B, RELN Specificity 4 % Genes 100 %
Autism NGS Panel. By Fulgent Genetics Fulgent Genetics (United States). RPL10, BDNF, SCN1A, SCN2A, BRAF, SLC6A4, SLC9A6, SMC1A, KDM5C, SNRPN, SOX5, SPAST, ST7, STK3, CDKL5, TCF4, MED12, TSC1, TSC2, UBE3A , (...) View the complete list with 78 more genes Panel complete gene list RPL10, BDNF, SCN1A, SCN2A, BRAF, SLC6A4, SLC9A6, SMC1A, KDM5C, SNRPN, SOX5, SPAST, ST7, STK3, CDKL5, TCF4, MED12, TSC1, TSC2, UBE3A, CNTNAP2, FOXP2, CACNA1C, NSD1, AUTS2, PCDH19, NLGN4X, NLGN3, SHANK3, SHANK2, IMMP2L, ZEB2, CASK, RAB39B, NEGR1, SMG6, ARX, PHF6, RBFOX1, CNTNAP5, DOCK4, CHD8, MBD5, CHD7, SLC9A9, DPP10, ANKRD11, SATB2, ZNF804A, VPS13B, KCTD13, KIRREL3, NTNG1, CREBBP, EHMT1, KATNAL2, PTCHD1, DHCR7, NIPBL, DLGAP2, DMD, DPP6, FGD1, FMR1, FOLR1, FOXG1, FOXP1, GABRB3, GABRG1, GNA14, GRIN2B, GRPR, HOXA1, HPRT1, AP1S2, KLHL3, L1CAM, LAMC3, MECP2, MEF2C, MET, MID1, NHS, NRXN1, OPHN1, PAFAH1B1, PCDH9, PDE10A, ATRX, AVPR1A, PIP5K1B, PNKP, PON3, PQBP1, PTEN, PTPN11, RAI1, RELN Specificity 2 % Genes 100 %
Intellectual Disability NGS Panel. By Fulgent Genetics Fulgent Genetics (United States). BCS1L, RPS6KA3, SACS, BIN1, SCN1A, SCN8A, SDCCAG8, SGCA, SGSH, ST3GAL3, SLC16A2, SLC20A2, SLC25A12, SLC25A13, SLC25A15, SLC2A1, SLC2A2, BRCA2, SLC4A4, SLC5A2 , (...) View the complete list with 367 more genes Panel complete gene list BCS1L, RPS6KA3, SACS, BIN1, SCN1A, SCN8A, SDCCAG8, SGCA, SGSH, ST3GAL3, SLC16A2, SLC20A2, SLC25A12, SLC25A13, SLC25A15, SLC2A1, SLC2A2, BRCA2, SLC4A4, SLC5A2, SLC5A5, SLC6A4, SLC6A8, SLC7A7, SLC9A6, SMARCA4, SMARCB1, ARID1A, SMC1A, KDM5C, SMS, SOX10, SOX2, SOX3, ATL1, SPR, SPTAN1, SPTLC1, STAT5B, CDKL5, STX11, STXBP1, SUCLG1, BUB1B, SYNGAP1, SYP, TBCE, TBX1, TGIF1, TH, THRB, TINF2, TSPAN7, ACOX1, TSC1, TSC2, CEP41, TTR, TUBA8, TWIST1, UBE2A, UBE3A, USP9X, VLDLR, WRN, XIST, ZIC2, ZBTB16, MRAP, FTSJ1, HDAC8, MCOLN1, NSDHL, GFM1, CNTNAP2, ABCG5, CACNG2, HDAC4, PCDH19, NLGN3, SHANK3, SHANK2, IRX5, NHP2, ELOVL4, NPC2, COG5, ZEB2, CASK, MBTPS2, CBS, NDUFAF5, SAMHD1, PCNT, UPB1, RAB39B, HAX1, PRICKLE1, CPA6, BRWD3, TPK1, CDH15, ACY1, PDSS1, CDKN1C, FKRP, ARID1B, ARX, TMCO1, ATP6AP2, ZDHHC9, COG7, ZFP57, CAMTA1, ASPM, POMGNT1, KIF21A, ALG12, CHRNA4, LYST, CANT1, POMT2, CCDC88C, SLC35C1, UPF3B, MBD5, BRIP1, CHD7, PHF8, TPH2, CLN3, ZFYVE26, TUBA1A, TUBB3, ZBTB24, PDHX, RFX6, AHI1, SATB2, VPS13B, KCTD7, COL1A2, ADAR, CP, GNPTG, LMBRD1, SYT14, ALG6, KIRREL3, PIGO, CRADD, TTC37, MED23, MED17, SLX4, GLYCTK, WDR62, FAM126A, SIL1, EHMT1, FTO, G6PC3, TMEM216, CTNNB1, MMADHC, RAB40AL, DARS2, CUL4B, OFD1, NHEJ1, SRD5A3, NSUN2, PIGV, CYP27A1, TMEM70, CTC1, HEPACAM, UROC1, WDR81, AMER1, DBT, XPNPEP3, D2HGDH, TMEM67, MFSD8, DHCR24, DHCR7, CYB5R3, NIPBL, MAGT1, DLG3, CEP290, IQSEC2, ADSL, RPGRIP1L, TBC1D24, SHROOM4, CC2D2A, SOBP, DMD, DIP2B, DYNC1H1, MTFMT, GNPTAB, BBS9, DPYD, CRBN, ATP13A2, CC2D1A, TUSC3, KIF7, SLC46A1, SNIP1, STRA6, SRPX2, TMEM165, CEP57, TUBB2B, TRAPPC9, HUWE1, DYRK1A, EBP, AFP, AGL, EFNB1, ALG11, AGTR2, ERCC2, ERCC3, ERCC5, ERCC6, ERCC8, F5, ACSL4, FANCG, FBLN5, FBN1, FBN2, FKTN, FGD1, FGF14, FGFR1, FGFR2, FGFR3, FMR1, AFF2, FOXG1, FOXP1, ALDH4A1, GABRG2, GALE, GAMT, GAN, GBA, GBE1, GCK, GDI1, GFAP, GHR, GLI3, GLRA1, GLUL, GM2A, GNAS, GNPAT, ALX4, TECR, GRIA3, GRIK2, GRIN1, GRIN2A, GRIN2B, GRM1, GSS, GUSB, GYS2, HSD17B10, HEXB, HOXD10, HPD, HSPD1, IDS, IGBP1, IGF1, IGF1R, AP1S1, AP1S2, AP3B1, ABCC6, AP4B1, AP4E1, AP4M1, AP4S1, IL1RAPL1, INSR, ABCD1, ITGA7, KCNJ10, KCNJ11, KCNK9, KCNQ2, KIF5A, KIF11, AQP7, KRAS, AR, L1CAM, LAMA2, LAMP2, LARGE1, LBR, LHX3, LIG4, ARG1, LRP5, MAN1B1, MAN2B1, MANBA, ARHGEF6, MAPT, MAT1A, MCCC1, MCCC2, MCPH1, MECP2, MEF2C, MGAT2, MKKS, MOCS2, MPI, MPZ, MTHFR, MTR, MYCN, ASS1, MYO5A, MYO7A, NAGA, NBN, NDP, NDUFA1, NDUFS1, NF1, NGF, NPC1, NPHP3, ATM, ATP1A2, NRXN1, OPHN1, ORC1, PAFAH1B1, PAH, PAK3, PAX6, ATP7A, AIFM1, PDE4D, ATRX, PEX7, KIF1A, PGK1, AUH, PHKA2, PHKG2, AVP, PIGL, AVPR2, PLA2G6, PLP1, POMT1, POU1F1, CTSA, PPOX, ACAT1, PQBP1, PRKAR1A, PRSS12, PTEN, PTPN11, PYCR1, ALDH18A1, PYGL, RAI1, RAPSN, RBBP8, RBM10 Specificity 1 % Genes 100 %
Serotonin Metabolism Deficiency NGS Panel. By Fulgent Genetics Fulgent Genetics (United States). SLC6A4, TPH1, AANAT, TPH2, HTR3C, HTR3E, DDC, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR5A, HTR6, HTR7 Specificity 6 % Genes 100 %
SLC6A4. By Fulgent Genetics Fulgent Genetics (United States). SLC6A4 Specificity 100 % Genes 100 %
SLC6A4. By Genelex (United States). SLC6A4 Specificity 100 % Genes 100 %

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Sources and references

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