Colorectal Cancer; Crc
Description
Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and environmental risk factors, gene defects can contribute to an inherited predisposition to CRC. CRC is caused by changes in different molecular pathogenic pathways, such as chromosomal instability, CpG island methylator phenotype, and microsatellite instability. Chromosome instability is the most common alteration and is present in almost 85% of all cases (review by Schweiger et al., 2013).
Genes related to Colorectal Cancer; Crc
- FGFR3
- TP53
- FLCN
- PIK3CA
- AKT1
- MLH3
- AURKA
- RAD54B
- CTNNB1
- ODC1
- SRC
- EP300
- CCND1
- PTPN12
- APC
- TLR2
- DCC
- PTPRJ
- DLC1
- PDGFRL
- BAX
- BUB1B
- NRAS
- MCC
- AXIN2
- PLA2G2A
Clinical Features
Top most frequent phenotypes and symptoms related to Colorectal Cancer; Crc
- Neoplasm
- Carcinoma
- Oligodontia
- Colon cancer
- Colitis
- Renal cell carcinoma
- Ulcerative colitis
- Retinoblastoma
- Leiomyosarcoma
- Endometrial carcinoma
And another 5 symptoms. If you need more information about this disease we can help you.
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Colorectal Cancer; Crc Is also known as colon cancer.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Colorectal Cancer; Crc Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
---|
Achondroplasia Mutation Panel.
By Baylor Miraca Genetics Laboratories (United States).
FGFR3
Specificity
100 %
Genes
4 % |
PreSeek Non-invasive Prenatal Gene Sequencing Screen.
By Baylor Miraca Genetics Laboratories (United States).
RIT1, BRAF, SMC1A, SOS1, SOS2, CDKL5, SYNGAP1, TSC1, TSC2, HDAC8, NSD1, CBL, SHOC2, CHD7, COL1A2, SMC3, NIPBL, FGFR2, FGFR3, HRAS , (...)
View the complete list with 9 more genes
Specificity
7 %
Genes
8 % |
Epilepsy Advanced Sequencing and CNV Evaluation - Developmental Brain Malformations.
By Athena Diagnostics Inc (United States).
SHH, STIL, SIX3, TUBA8, SLC25A19, DEAF1, ARFGEF2, RAB3GAP1, CENPJ, NDE1, FKRP, ARX, ASPM, POMGNT1, POMT2, TUBA1A, COL4A1, CPT2, WDR62, DCX , (...)
View the complete list with 20 more genes
Specificity
3 %
Genes
4 % |
Epilepsy Advanced Sequencing and CNV Evaluation.
By Athena Diagnostics Inc (United States).
SCN1A, SCN1B, SCN2A, SCN3A, SCN5A, SCN8A, SCN9A, SHH, ST3GAL3, ST3GAL5, STIL, SIX3, SLC2A1, SLC35A2, SLC6A1, SLC6A8, SLC9A6, SMC1A, KDM5C, SMS , (...)
View the complete list with 214 more genes
Specificity
1 %
Genes
4 % |
Hearing Loss Advanced Sequencing and CNV Evaluation.
By Athena Diagnostics Inc (United States).
BCS1L, ROR1, SALL1, SEMA3E, SIX1, SIX5, SLC12A1, SLC19A2, SLC22A4, SNAI2, SMPX, SOX10, TBX1, TCOF1, TECTA, TFAP2A, TIMM8A, TJP2, TMPRSS3, USH1C , (...)
View the complete list with 149 more genes
Specificity
1 %
Genes
4 % |
Non-immune Hydrops Panel.
By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).
RIT1, RPL11, RPL35A, RPL5, RPS10, RPS17, RPS19, RPS24, RPS26, SEC23B, SLC17A5, BRAF, SMPD1, SOS1, SOS2, SOX18, UROS, CBL, SHOC2, ALG9 , (...)
View the complete list with 66 more genes
Specificity
3 %
Genes
8 % |
NGS Skeletal Dysplasia Panel.
By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).
SLC26A2, SOX9, TRPV4, COL1A2, COMP, FGFR3, FLNA, HSPG2
Specificity
13 %
Genes
4 % |
FGFR3-related disorders.
By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).
FGFR3
Specificity
100 %
Genes
4 % |
You can get up to 1196 more panels with our dedicated tool
Learn moreSources and references
You can check the following sources for additional information.
OMIM Rare Disease Search EngineIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like TESTICULAR MICROLITHIASIS TARP SYNDROME; TARPS NEURALGIC AMYOTROPHY