Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5

Table of contents:

Description
Related genes
Clinical Features
Incidence and onset information
Alternative Names
Researches and researchers
Gene Panels
Sources and references

Description

Hereditary nonpolyposis colorectal cancer type 5 is a cancer predisposition syndrome characterized by onset of colorectal cancer and/or extracolonic cancers, particularly endometrial cancer, usually in mid-adulthood. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Castellsague et al., 2015).For a phenotypic description and a discussion of genetic heterogeneity of hereditary nonpolyposis colorectal cancer (HNPCC), see HNPCC1 (OMIM ).

Genes related to Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5

MSH6

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Clinical Features

Top most frequent phenotypes and symptoms related to Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5

Neoplasm
Carcinoma
Lymphoma
Breast carcinoma
Colon cancer
Ovarian neoplasm
Hodgkin lymphoma
Neoplasm of the pancreas
Stomach cancer
Ovarian carcinoma

And another 2 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Colorectal Cancer, Hereditary Nonpolyposis, Type 5; Hnpcc5 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
HNPCC MSI & IHC Screening. By Baylor Miraca Genetics Laboratories (United States). EPCAM, MLH1, MSH2, MSH6, PMS2 Specificity 20 % Genes 100 %
MSH6 Comprehensive - Sequence & Deletion/Duplication Analysis. By Baylor Miraca Genetics Laboratories (United States). MSH6 Specificity 100 % Genes 100 %
MSH6 Deletion/Duplication Analysis. By Baylor Miraca Genetics Laboratories (United States). MSH6 Specificity 100 % Genes 100 %
MSH6 Sequence Analysis. By Baylor Miraca Genetics Laboratories (United States). MSH6 Specificity 100 % Genes 100 %
MSH6 Sequence Analysis (Familial Mutation/Variant Analysis). By Baylor Miraca Genetics Laboratories (United States). MSH6 Specificity 100 % Genes 100 %
Mismatch Repair Proteins Immunohistochemistry. By Baylor Miraca Genetics Laboratories (United States). MLH1, MSH2, MSH6, PMS2 Specificity 25 % Genes 100 %
Hereditary Brain, CNS, PNS Cancer Panel. By Baylor Miraca Genetics Laboratories (United States). TP53, VHL, SUFU, PALB2, ALK, APC, MEN1, MLH1, MRE11, MSH2, MSH6, NBN, NF2, ATM, PMS2, PHOX2B, PTCH1 Specificity 6 % Genes 100 %
Hereditary Brain, CNS, PNS Cancer Panel. By Baylor Miraca Genetics Laboratories (United States). TP53, VHL, SUFU, PALB2, ALK, APC, MEN1, MLH1, MRE11, MSH2, MSH6, NBN, NF2, ATM, PMS2, PHOX2B, PTCH1 Specificity 6 % Genes 100 %

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Sources and references

You can check the following sources for additional information.

MESH OMIM Rare Disease Symptoms Checker

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