Kaposi Sarcoma, Susceptibility To
Description
Kaposi sarcoma (KS) is an invasive angioproliferative inflammatory condition that occurs commonly in men infected with human immunodeficiency virus (HIV; see {609423}). In the early stages of KS, lesions appear reactive and are stimulated to grow by the actions of inflammatory cytokines and growth factors. In the late stages of KS, a malignant phenotype that appears to be monoclonal can develop. Infection with human herpesvirus-8 (HHV-8), also known as KS-associated herpesvirus (KSHV), is necessary but not sufficient for KS development. Coinfection with HIV markedly increases the likelihood of KS development, and additional environmental, hormonal, and genetic cofactors likely contribute to its pathogenesis (summary by Foster et al., 2000).Suthaus et al. (2012) noted that HHV-8 is the etiologic agent not only of KS, but also of primary effusion lymphoma and plasma cell-type multicentric Castleman disease (MCD).
Genes related to Kaposi Sarcoma, Susceptibility To
- IL6
Clinical Features
Top most frequent phenotypes and symptoms related to Kaposi Sarcoma, Susceptibility To
- Milia
- Neoplasm
- Hypertension
- Tics
- Edema
- Coma
- Pneumonia
- Immunodeficiency
- Lymphadenopathy
- Lymphoma
Incidence and onset information
— Not enough data available about incidence and published cases.
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Kaposi Sarcoma, Susceptibility To Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
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Crohn Disease.
By Bioscientia GmbH Center for Human Genetics in Germany.
NOD2, IL6
Specificity
50 %
Genes
100 % |
IL6.
By Fulgent Genetics Fulgent Genetics in United States.
IL6
Specificity
100 %
Genes
100 % |
OmniSeq Comprehensive.
By OmniSeq, Inc. in United States.
BRCA1, BRCA2, VHL, APC, MSH2, MLH1, PTEN, TP53, FOXL2, HNF1A, PPARG, WT1, RB1, RET, RAF1, IDH2, SOX2, STAT3, PNP, FGFR3 , (...)
View the complete list with 124 more genes
Specificity
1 %
Genes
100 % |
Inflammatory Bowel Disease (IBD) and Related Disorders , Panel Massive Sequencing (NGS) 46 Genes.
By Reference Laboratory Genetics in Spain.
TGFB1, CYBA, IL2RG, IKBKG, TINF2, CYBB, WAS, GATA3, FOXP1, FOXP3, DKC1, ABCB1, TERC, TERT, SH2D1A, NCF2, NCF4, WRAP53, NOD2, CD40LG , (...)
View the complete list with 25 more genes
Specificity
3 %
Genes
100 % |
Alternate names
Kaposi Sarcoma, Susceptibility To Is also known as multiple idiopathic pigmented hemangiosarcoma, susceptibility to.
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