Lactose Intolerance, Adult Type
Description
In humans, the activities of lactase and most of the other digestive hydrolases are maximal at birth. The majority of the world's human population experiences a decline in production of the digestive enzyme lactase-phlorizin hydrolase during maturation, with the age of onset ranging from the toddler years to young adulthood. Due to the reduced lactase level, lactose present in dairy products cannot be digested in the small intestine and instead is fermented by bacteria in the distal ileum and colon. The fermentative products result in symptoms of diarrhea, gas bloat, flatulence, and abdominal pain. However, in a minority of adults, high levels of lactase activity persist in adulthood. Lactase persistence is a heritable autosomal dominant condition that results in a sustained ability to digest the milk sugar lactose throughout adulthood (Olds and Sibley, 2003).
Clinical Features
Phenotypes and symptoms related to Lactose Intolerance, Adult Type
- Pain
- Diarrhea
- Abnormality of metabolism/homeostasis
- Osteoporosis
- Abdominal pain
- Gastritis
- Lactose intolerance
- Decreased small intestinal mucosa lactase activity
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Lactose Intolerance, Adult Type Is also known as adult lactase deficiency, disaccharide intolerance iii, hypolactasia, adult type.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Lactose Intolerance, Adult Type Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
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![]() By GENE Núcleo de Genética Médica de Minas Gerais (Brazil).
MCM6
Specificity
100 %
Genes
100 % |
![]() By Instituto de Medicina Genomica Instituto de Medicina Genomica (Spain).
MCM6
Specificity
100 %
Genes
100 % |
![]() By CGC Genetics (Portugal).
MCM6
Specificity
100 %
Genes
100 % |
![]() By CGC Genetics (Portugal).
MCM6
Specificity
100 %
Genes
100 % |
![]() By CGC Genetics (Portugal).
HLA-DQA1, HLA-DQB1, MCM6
Specificity
34 %
Genes
100 % |
![]() By Bioscientia GmbH Center for Human Genetics (Germany).
MCM6
Specificity
100 %
Genes
100 % |
![]() By Centogene AG - the Rare Disease Company (Germany).
MCM6
Specificity
100 %
Genes
100 % |
![]() By Furst Medical Laboratories, FurstNAT (Norway).
MCM6
Specificity
100 %
Genes
100 % |
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Learn moreSources and references
You can check the following sources for additional information.
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