Mirror Movements 1; Mrmv1

Description

Mirror movements are contralateral involuntary movements that mirror voluntary ones. Whereas mirror movements are occasionally found in normal young children, persistence beyond the age of 10 years is abnormal. Congenital mirror movements tend to persist throughout adulthood and tend to occur more commonly in the upper extremities (summary by Sharafaddinzadeh et al., 2008 and Srour et al., 2010). Some patients with DCC mutations have agenesis of the corpus callosum (Marsh et al., 2017). Genetic Heterogeneity of Mirror MovementsSee also MRMV2 (OMIM ), caused by mutation in the RAD51 gene (OMIM ) on chromosome 15q15, and MRMV3 (OMIM ), caused by mutation in the DNAL4 gene (OMIM ) on chromosome 22q13.

Clinical Features

• Pain
• Delayed speech and language development
• Intellectual disability, mild
• Agenesis of corpus callosum
• Abnormality of the nervous system
• Clumsiness
• Involuntary movements
• Partial agenesis of the corpus callosum
• Bimanual synkinesia