Periodic Fever, Menstrual Cycle-dependent

Description

Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. Rare menstrual cycle-dependent febrile episodes have been reported, some of which have shown a luteal-phase-dependent pattern (summary by Jiang et al., 2012).

Clinical Features

Phenotypes and symptoms related to Periodic Fever, Menstrual Cycle-dependent

  • Ataxia
  • Fever
  • Tremor
  • Myalgia
  • Lower limb muscle weakness
  • Migraine
  • Hepatitis
  • Increased circulating cortisol level
  • Recurrent spontaneous abortion

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Periodic Fever, Menstrual Cycle-dependent Recommended genes panels

Panel Name, Specifity and genes Tested/covered
HTR1A.

By Institute for Human Genetics University Clinic Freiburg (Germany).

HTR1A
Specificity
100 %
Genes
100 %
Serotonin Metabolism Deficiency NGS Panel.

By Fulgent Genetics Fulgent Genetics (United States).

SLC6A4, TPH1, AANAT, TPH2, HTR3C, HTR3E, DDC, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR5A, HTR6, HTR7
Specificity
6 %
Genes
100 %
HTR1A.

By Fulgent Genetics Fulgent Genetics (United States).

HTR1A
Specificity
100 %
Genes
100 %
Paroxetine response.

By Xcode Life Xcode Life (India).

CYP2D6, HTR1A
Specificity
50 %
Genes
100 %
Fluvoxamine response.

By Xcode Life Xcode Life (India).

CYP2D6, HTR1A
Specificity
50 %
Genes
100 %
Tempus xO assay.

By Tempus Labs, Inc. (United States).

BCL6, RHEB, RIPK1, RIPK2, RIPK3, RIT1, BCL7A, BCL9, BCR, ROBO2, ROCK1, ROCK2, ROR1, ROR2, ROS1, RPA1, BDNF, RPL5, RPN1, RPS6KB1 , (...)

View the complete list with 1627 more genes
Specificity
1 %
Genes
100 %

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Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Search Engine

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