Renal Cell Carcinoma, Nonpapillary; Rcc
Description
The Heidelberg histologic classification of renal cell tumors subdivides renal cell tumors into benign and malignant parenchymal neoplasms and, where possible, limits each subcategory to the most common documented genetic abnormalities (Kovacs et al., 1997). Malignant tumors are subclassified into common or conventional renal cell carcinoma (clear cell); papillary renal cell carcinoma; chromophobe renal cell carcinoma; collecting duct carcinoma, with medullary carcinoma of the kidney; and unclassified renal cell carcinoma. The common or conventional type accounts for about 75% of renal cell neoplasms and is characterized genetically by a highly specific deletion of chromosome 3p. Papillary renal cell carcinoma (see {605074}) accounts for about 10% of renal cell tumors. Chromophobe renal cell carcinoma accounts for approximately 5% of renal cell neoplasms. Genetically, chromophobe RCC is characterized by a combination of loss of heterozygosity of chromosomes 1, 2, 6, 10, 13, 17, and 21 and hypodiploid DNA content. Collecting duct carcinoma accounts for about 1% of renal cell carcinoma.Renal cell carcinoma occurs nearly twice as often in men as in women; incidence in the United States is equivalent among whites and blacks. Cigarette smoking doubles the likelihood of renal cell carcinoma and contributes to as many as one-third of cases. Obesity is also a risk factor, particularly in women. Other risk factors include hypertension, unopposed estrogen therapy, and occupational exposure to petroleum products, heavy metals, or asbestos (summary by Motzer et al., 1996).
Genes related to Renal Cell Carcinoma, Nonpapillary; Rcc
- FLCN
- VHL
- HNF1A
- HNF1B
- TMEM127
- RNF139
- SLC49A4
- OGG1
Clinical Features
Top most frequent phenotypes and symptoms related to Renal Cell Carcinoma, Nonpapillary; Rcc
- Neoplasm
- Hypertension
- Obesity
- Carcinoma
- Falls
- Renal cyst
- Lymphoma
- Melanoma
- Nephroblastoma
- Polycythemia
And another 10 symptoms. If you need more information about this disease we can help you.
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Renal Cell Carcinoma, Nonpapillary; Rcc Is also known as hypernephroma, adenocarcinoma of kidney.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Renal Cell Carcinoma, Nonpapillary; Rcc Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
---|
Hereditary Renal Cancer Panel.
By Baylor Miraca Genetics Laboratories (United States).
SDHA, SDHB, SDHC, SDHD, VHL, WT1, CDKN1C, SDHAF2, FLCN, FH, GPC3, MET, PTEN
Specificity
16 %
Genes
25 % |
Comprehensive Hereditary Cancer Panel.
By Baylor Miraca Genetics Laboratories (United States).
RUNX1, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, VHL, WT1, CBL, SUFU, CDC73, CDH1, CDK4, CDKN1C, CDKN2A , (...)
View the complete list with 39 more genes
Specificity
6 %
Genes
38 % |
Comprehensive Pulmonary Panel.
By Greenwood Genetic Center Diagnostic Laboratories Greenwood Genetic Center (United States).
RPGR, SCNN1A, SCNN1B, SCNN1G, BMPR1B, BMPR2, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, SLC7A7, SPAG1, STAT3, TERC, TERT, TINF2, NKX2-1, TSC1, TSC2 , (...)
View the complete list with 73 more genes
Specificity
2 %
Genes
13 % |
Inherited Cancer Panel.
By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University (United States).
BLM, SDHB, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, TSC1, TSC2, VHL, XRCC2, CDC73, CDH1, CDK4, CDKN1B, CDKN2A, BRIP1, SDHAF2, TMEM127 , (...)
View the complete list with 28 more genes
Specificity
7 %
Genes
38 % |
VistaSeq Renal Cell Cancer Panel.
By Molecular Diagnostic Laboratory University of Alberta (Canada).
SDHB, SDHC, SDHD, EPCAM, TP53, TSC1, TSC2, VHL, WT1, FLCN, FH, GPC3, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN
Specificity
11 %
Genes
25 % |
FLCN.
By Institute for Human Genetics University Clinic Freiburg (Germany).
FLCN
Specificity
100 %
Genes
13 % |
Cystic Lung Disease Panel (8 Genes).
By Laboratory for Molecular Medicine Partners HealthCare Personalized Medicine (United States).
TSC1, TSC2, FLCN, EFEMP2, ELN, FBLN5, LTBP4, SERPINA1
Specificity
13 %
Genes
13 % |
PulmoGene Panel (64 Genes).
By Laboratory for Molecular Medicine Partners HealthCare Personalized Medicine (United States).
RPGR, BDNF, SCNN1A, SCNN1B, SCNN1G, BMPR2, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, STAT3, TERC, TERT, NKX2-1, TSC1, TSC2, RSPH1, HPS3, HPS4 , (...)
View the complete list with 44 more genes
Specificity
2 %
Genes
13 % |
You can get up to 467 more panels with our dedicated tool
Learn moreSources and references
You can check the following sources for additional information.
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