Spondyloepimetaphyseal Dysplasia, GeneviÈve Type
Description
Spondyloepimetaphyseal dysplasia, Geneviève type is a rare primary bone dysplasia characterized by severe developmental delay and skeletal dysplasia (including short stature, premature carpal ossification, platyspondyly, longitudinal metaphyseal striations, and small epiphyses), as well as moderate to severe intellectual disability and facial dysmorphism, including prominent forehead, mild synophrys, depressed nasal bridge, prominent bulbous nasal tip and full lips.
Genes related to Spondyloepimetaphyseal Dysplasia, GeneviÈve Type
- NANS
Clinical Features
Top most frequent phenotypes and symptoms related to Spondyloepimetaphyseal Dysplasia, GeneviÈve Type
- Intellectual disability
- Seizures
- Global developmental delay
- Short stature
- Generalized hypotonia
- Microcephaly
- Ataxia
- Nystagmus
- Strabismus
- Abnormal facial shape
And another 44 symptoms. If you need more information about this disease we can help you.
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Spondyloepimetaphyseal Dysplasia, GeneviÈve Type Is also known as nans deficiency, semd, genevieve type, semdg, semd, geneviÈve type.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Spondyloepimetaphyseal Dysplasia, GeneviÈve Type Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
---|
Spondylo-Epi-Metaphyseal dysplasias Deletion / Duplication panel.
By Connective Tissue Gene Tests (United States).
RMRP, BGN, RUNX2, SLC26A2, SMARCAL1, ACP5, CFAP410, CCN6, XYLT1, RAB33B, B3GALT6, TRPV4, NANS, SBDS, CHST3, CANT1, DYM, COL10A1, COL11A1, COL11A2 , (...)
View the complete list with 33 more genes
Specificity
2 %
Genes
100 % |
Spondylo-Epi-Metaphyseal dysplasias Comprehensive panel.
By Connective Tissue Gene Tests (United States).
RMRP, BGN, RUNX2, SLC26A2, SMARCAL1, ACP5, CFAP410, CCN6, XYLT1, RAB33B, B3GALT6, TRPV4, NANS, SBDS, CHST3, CANT1, DYM, COL10A1, COL11A1, COL11A2 , (...)
View the complete list with 33 more genes
Specificity
2 %
Genes
100 % |
Spondylo-Epi-Metaphyseal dysplasias NGS panel.
By Connective Tissue Gene Tests (United States).
RMRP, BGN, RUNX2, SLC26A2, SMARCAL1, ACP5, CFAP410, CCN6, XYLT1, RAB33B, B3GALT6, TRPV4, NANS, SBDS, CHST3, CANT1, DYM, COL10A1, COL11A1, COL11A2 , (...)
View the complete list with 33 more genes
Specificity
2 %
Genes
100 % |
NANS.
By Fulgent Genetics Fulgent Genetics (United States).
NANS
Specificity
100 %
Genes
100 % |
Comprehensive Skeletal Dysplasias and Disorders Panel.
By Blueprint Genetics (Finland).
RMRP, ROR2, BGN, RUNX2, BMP1, BMP2, BMPR1B, SF3B4, SH3BP2, SHOX, SKI, SLCO2A1, SLC26A2, SMARCAL1, SMC1A, SOX9, TBX15, TBX3, TBX4, TBX6 , (...)
View the complete list with 223 more genes
Specificity
1 %
Genes
100 % |
Comprehensive Growth Disorders / Skeletal Dysplasias and Disorders Panel.
By Blueprint Genetics (Finland).
RIT1, RMRP, BCS1L, ROR2, BGN, RRAS, RUNX2, BMP1, BMP2, SEC24D, BMPR1B, SF3B4, SH3BP2, SHOX, SKI, SLCO2A1, BRAF, SLC26A2, SMARCAL1, SMC1A , (...)
View the complete list with 284 more genes
Specificity
1 %
Genes
100 % |
You can get up to -2 more panels with our dedicated tool
Learn moreSources and references
You can check the following sources for additional information.
OMIM ORPHANET MESH Rare Disease Symptoms CheckerIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like WAARDENBURG SYNDROME, TYPE 2E; WS2E COFFIN-SIRIS SYNDROME MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 1; MVA1 CONGENITAL MYOPATHY WITH MYASTHENIC-LIKE ONSET