Vertical Talus, Congenital; Cvt
Description
Congenital vertical talus (CVT), also known as 'rocker-bottom foot' deformity, is a dislocation of the talonavicular joint characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence (summary by Levinsohn et al., 2004). The condition is transmitted in an autosomal dominant pattern of inheritance, and sometimes shows incomplete penetrance and variable expressivity. There may be a broad spectrum of deformities, including flatfoot, talipes equinovarus (TEV or clubfoot), cavus foot, metatarsus adductus, and even hypoplasia of the tibia (summary by Dobbs et al., 2006).
Clinical Features
Top most frequent phenotypes and symptoms related to Vertical Talus, Congenital; Cvt
- Pain
- Flexion contracture
- Talipes equinovarus
- Arthritis
- Abnormality of the foot
- Talipes
- Rocker bottom foot
- Metatarsus adductus
- Short tibia
- Calcaneovalgus deformity
And another 1 symptoms. If you need more information about this disease we can help you.
Incidence and onset information
— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)— No data available about the known clinical features onset.
Alternative names
Vertical Talus, Congenital; Cvt Is also known as pes valgus, congenital convex, rocker-bottom foot.
Researches and researchers
Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.Vertical Talus, Congenital; Cvt Recommended genes panels
Panel Name, Specifity and genes Tested/covered |
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Charcot-Marie-Tooth (CMT) and Related Hereditary Neuropathies, PMP22 Deletion/Duplication with Reflex to Sequencing Panel.
By ARUP Laboratories, Molecular Genetics and Genomics (United States).
SBF1, SCN9A, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, TFG, YARS, PRX, SLC5A7, ARHGEF10, WNK1, BSCL2, GDAP1, TRIM2, CCT5, KIF1B, LITAF, FIG4 , (...)
View the complete list with 58 more genes
Specificity
2 %
Genes
100 % |
Charcot-Marie-Tooth (CMT) and Related Hereditary Neuropathies Panel, Sequencing.
By ARUP Laboratories, Molecular Genetics and Genomics (United States).
SBF1, SCN9A, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, TFG, YARS, PRX, SLC5A7, ARHGEF10, WNK1, BSCL2, GDAP1, TRIM2, CCT5, KIF1B, LITAF, FIG4 , (...)
View the complete list with 58 more genes
Specificity
2 %
Genes
100 % |
Hereditary peripheral neuropathies, including Charcot-Marie-Tooth disease (NGS panel for 74 genes).
By CGC Genetics (Portugal).
SBF1, SCN11A, SCN9A, DST, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, TWNK, TFG, TTR, YARS, PRX, ARHGEF10, WNK1, BSCL2, ABHD12, GDAP1, TRIM2 , (...)
View the complete list with 54 more genes
Specificity
2 %
Genes
100 % |
Charcot-Marie-Tooth disease (NGS panel for 43 genes).
By CGC Genetics (Portugal).
SBF1, YARS, PRX, GDAP1, TRIM2, KIF1B, LITAF, FIG4, MFN2, TRPV4, FGD4, AARS, GNB4, SBF2, COX6A1, DHTKD1, INF2, LRSAM1, C12orf65, MED25 , (...)
View the complete list with 23 more genes
Specificity
3 %
Genes
100 % |
Congenital vertical talus (sequence analysis of HOXD10 gene).
By CGC Genetics (Portugal).
HOXD10
Specificity
100 %
Genes
100 % |
Congenital vertical talus (sequence analysis of HOXD10 gene).
By CGC Genetics (Portugal).
HOXD10
Specificity
100 %
Genes
100 % |
AllNeuro panel.
By Centogene AG - the Rare Disease Company (Germany).
BCS1L, ROR2, RPL10, BDNF, RPS6KA3, RTN2, RYR1, SACS, BIN1, SBF1, SCN10A, SCN1A, SCN1B, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A, SCO1 , (...)
View the complete list with 1177 more genes
Specificity
1 %
Genes
100 % |
Charcot-Marie-Tooth and Sensory Neuropathies Panel.
By CeGaT GmbH (Germany).
SBF1, SCN10A, SCN11A, SCN9A, DST, SLC12A6, SOX10, ATL1, SPTLC1, SPTLC2, SURF1, TWNK, TFG, TTR, YARS, PRX, ARHGEF10, WNK1, BSCL2, ABHD12 , (...)
View the complete list with 64 more genes
Specificity
2 %
Genes
100 % |
You can get up to 5 more panels with our dedicated tool
Learn moreSources and references
You can check the following sources for additional information.
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