BCL6 gene related symptoms and diseases
All the information presented here about the BCL6 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,OMIM,HGNC,ORPHANET, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to BCL6 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Neoplasm | Rare - less than 30% cases |
| Insulin resistance | Rare - less than 30% cases |
| Mediastinal lymphadenopathy | Rare - less than 30% cases |
| Skin nodule | Rare - less than 30% cases |
| Night sweats | Rare - less than 30% cases |
Other less frequent symptoms and clinical features
Patients with BCL6 gene alterations may also develop some of the following symptoms and phenotypes:Rarely - Less than 30% cases
- Chronic lymphatic leukemia
- B-cell lymphoma
- Glucose intolerance
- Pleural effusion
- Meningitis
- Lymphedema
- Lymphoma
- Fever
And 10 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to BCL6 gene
Here you will find a list of rare diseases related to the BCL6. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA
Alternate names
PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA Is also known as med-dlbcl, primary mediastinal clear cell lymphoma of b-cell type, large cell lymphoma of the mediastinum, mediastinal diffuse large-cell lymphoma with sclerosis
Description
Primary mediastinal B-cell lymphoma (PMBL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL; see this term), arising from B cells of thymic origin, that affects mainly women between the ages of 20-30, that usually presents with a bulky and rapidly expanding anterior mediastinal mass, often with pleural and pericardial effusions, and that can invade the lungs, superior vena cava, pleura, pericardium, and chest wall, leading to manifestations of cough, dyspnea, and superior vena cava syndrome.
More info about PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA
SOURCES: ORPHANET
FOLLICULAR LYMPHOMA
Alternate names
FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2
Description
Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.
Most common symptoms of FOLLICULAR LYMPHOMA
- Neoplasm
- Fever
- Fatigue
- Diarrhea
- Splenomegaly
More info about FOLLICULAR LYMPHOMA
HIGH GRADE B-CELL LYMPHOMA WITH MYC AND/ OR BCL2 AND/OR BCL6 REARRANGEMENT
INTRAVASCULAR LARGE B-CELL LYMPHOMA
Alternate names
INTRAVASCULAR LARGE B-CELL LYMPHOMA Is also known as tappeiner-pfleger disease, angioendotheliomatosis proliferans systemisata, malignant angioendotheliomatosis, angiotropic large cell lymphoma, intravascular lymphomatosis
Description
Intravascular large B-cell lymphoma (IVLBCL) is a very rare form of diffuse large B-cell lymphoma (see this term) characterized by the selective growth of lymphoma cells within the lumina of small blood vessels (especially the capillaries) that most often presents with a wide range of clinical manifestations (as potentially any tissue can be involved), with patients from Western countries more frequently manifesting with neurological and cutaneous symptoms while patients from Asian countries more frequently displaying hepatosplenomegaly and thrombocytopenia. IVLBCL is characterized by an absence of lymphadenopathy, an aggressive clinical course and a poor prognosis.
More info about INTRAVASCULAR LARGE B-CELL LYMPHOMA
SOURCES: ORPHANET
Search interest in BCL6
Potential gene panels for BCL6 gene
Detection by FISH of BCL6 (3q27) rearrangements Panel
Portugal.
By CGC Genetics
This panel specifically test the BCL6 gene.
More info about this panel Portugal.
Detection by FISH of NHL diffuse large cells (t(14;18), t(8;14) and BCL6) Panel
Portugal.
By CGC Genetics
This panel specifically test the BCL6 gene.
More info about this panel Portugal.
Cancer Hotspot Panel Panel
Germany.
By Centogene AG - the Rare Disease Company Cancer Hotspot Panel that also includes the following genes: BCL6 ROS1 BRAF BRCA1 BRCA2 SMARCB1 SMO SRC STK11 HNF1A
More info about this panel Germany.
Fluorescent in situ Hybridization - Hematopathology Panel
United States.
By Hartford Hospital Laboratory - Molecular Genetics and Cytogenetics Hartford Hospital-Hartford-CT-USA Fluorescent in situ Hybridization - Hematopathology that also includes the following genes: BCL6 BCR RUNX1 ABI1 TCF3 TP53 DLEU1 CRLF2 RUNX1T1 CBFB
More info about this panel United States.
FISH, Lymphoma Panel Panel
United States.
By Cytogenetics and Molecular Pathology Laboratory UP Health System Marquette FISH, Lymphoma Panel that also includes the following genes: BCL6 CCND1 IGH MALT1 MYC
More info about this panel United States.
BCL6 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the BCL6 gene.
More info about this panel United States.
Onco microarray for CLL Panel
United States.
By Pittsburgh Cytogenetics Laboratory University of Pittsburgh Medical Center Onco microarray for CLL that also includes the following genes: BCL6 TP53 BCL11A CCND1 FGF2 AKT1 ALK IGH ITK MYB
More info about this panel United States.
Focus::DLBCL&FL™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::DLBCL&FL™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS
More info about this panel United States.
Focus::Lymphoma™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Lymphoma™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS
More info about this panel United States.
FoundationOne® Heme Panel
United States.
By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1
More info about this panel United States.
NeoTYPE® Discovery Profile for Solid Tumors Panel
United States.
By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2
More info about this panel United States.
Caris MI TumorSeek 592-Gene NGS Panel Panel
United States.
By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1
More info about this panel United States.
Tempus xT assay Panel
United States.
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panel United States.
Tempus xO assay Panel
United States.
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel United States.
If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like BCKDHA CDKAL1