CYP2B6 gene related symptoms and diseases

All the information presented here about the CYP2B6 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.

Table of contents:

Main symptoms and clinical features
Other symptoms and clinical features
Related Diseases
Current trends
Suitable testing panels

Top 5 symptoms and clinical features associated to CYP2B6 gene

Symptoms // Phenotype	% Cases
Immunodeficiency	Very Common - Between 80% and 100% cases
Depressivity	Very Common - Between 80% and 100% cases
Aggressive behavior	Very Common - Between 80% and 100% cases
Vertigo	Very Common - Between 80% and 100% cases
Insomnia	Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with CYP2B6 gene alterations may also develop some of the following symptoms and phenotypes:

Commonly - More than 50% cases
Mania

Rare diseases associated to CYP2B6 gene

Here you will find a list of rare diseases related to the CYP2B6. You can also use our tool to get a more accurate diagnosis based on your current symptoms.

EFAVIRENZ, POOR METABOLISM OF

Description

Highly active antiretroviral therapy (HAART) has reduced mortality associated with acquired immunodeficiency syndrome (AIDS; see {609423}) by at least 70%. Efavirenz is a non-nucleoside reverse transcriptase inhibitor that is frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. However, during the first weeks of therapy, up to half of patients who receive efavirenz experience CNS side effects, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, and such side effects may reflect varying efavirenz plasma concentrations. Plasma clearance of efavirenz appears slower in African Americans than in European Americans, and studies have suggested earlier virologic failure on efavirenz for both African Americans and Hispanics compared with European Americans. Efavirenz is metabolized primarily by hepatic CYP2B6, with some involvement of CYP3A (CYP3A4 ) (summary by Haas et al., 2004).

Most common symptoms of EFAVIRENZ, POOR METABOLISM OF

Immunodeficiency
Depressivity
Aggressive behavior
Vertigo
Insomnia

More info about EFAVIRENZ, POOR METABOLISM OF

SOURCES: OMIM

Search interest in CYP2B6

Potential gene panels for CYP2B6 gene

Efavirenz, poor metabolism of Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the CYP2B6 gene.

CYP2B6 gene related symptoms and diseases

Top 5 symptoms and clinical features associated to CYP2B6 gene

Other less frequent symptoms and clinical features

Commonly - More than 50% cases

Rare diseases associated to CYP2B6 gene

EFAVIRENZ, POOR METABOLISM OF

Description

Most common symptoms of EFAVIRENZ, POOR METABOLISM OF

Search interest in CYP2B6

Potential gene panels for CYP2B6 gene

Efavirenz, poor metabolism of Panel

Cytochrome P450 genotyping Panel

Pharmacogenetic panel Panel

CYP2B6 Panel

Toxicity to drugs: CYP2B6 gene sequence analysis Panel

CYP2B6 Panel

YouScript Analgesic Panel

CYP2B6 Panel

GeneSight Psychotropic Panel

Pain Medication DNA Insight Panel

Genecept Assay™ Panel

OneOme RightMed comprehensive test Panel

Rxight Pharmacogenetics Program Panel

CYP2B6 genotyping Panel

Susceptibility to Drugs (Efavirenz) , Sequencing CYP2B6 Gene Panel

Methadone response Panel

152 Integrated Advantage NGS Solid Tumor Panel Panel

Tempus xO assay Panel