REN gene related symptoms and diseases
All the information presented here about the REN gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,HGNC,ORPHANET,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to REN gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Renal insufficiency | Common - Between 50% and 80% cases |
| Nephropathy | Common - Between 50% and 80% cases |
| Intellectual disability | Uncommon - Between 30% and 50% cases |
| Vascular ring | Uncommon - Between 30% and 50% cases |
| Proximal tubulopathy | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with REN gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Decreased circulating renin level
- Right aortic arch
- Accessory spleen
- Widely patent fontanelles and sutures
- Absent gallbladder
- Anuria
- Aplasia of the thymus
- Potter facies
And 42 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to REN gene
Here you will find a list of rare diseases related to the REN. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
RENAL TUBULAR DYSGENESIS OF GENETIC ORIGIN
RENAL TUBULAR DYSGENESIS; RTD
Alternate names
RENAL TUBULAR DYSGENESIS; RTD Is also known as primitive renal tubule syndrome
Description
Autosomal recessive renal tubular dysgenesis is a severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype) (Gribouval et al., 2005). Absence or paucity of differentiated proximal tubules is the histopathologic hallmark of the disorder and may be associated with skull ossification defects.
Most common symptoms of RENAL TUBULAR DYSGENESIS; RTD
- Intellectual disability
- Microcephaly
- Hypertelorism
- Ventricular septal defect
- Respiratory insufficiency
More info about RENAL TUBULAR DYSGENESIS; RTD
REN-RELATED AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE
Alternate names
REN-RELATED AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE Is also known as early-onset hyperuricemia, anemia, and progressive kidney failure, ren-associated fjhn, ren-associated kidney disease, familial juvenile hyperuricemic nephropathy type 2, ren-associated familial juvenile hyperuricemic nephropathy, adtkd-ren, fjhn type 2
Description
Familial juvenile hyperuricemic nephropathy type 2 is a rare autosomal dominantly inherited disease of childhood characterized by hypoproliferative anemia, hyperuricemia and slowly progressing kidney failure due to dysregulation of the renin-angiotensin system (RAS).
Most common symptoms of REN-RELATED AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE
- Anemia
- Renal insufficiency
- Stage 5 chronic kidney disease
- Nephropathy
- Renal cyst
More info about REN-RELATED AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE
Search interest in REN
Potential gene panels for REN gene
Renal Cystic Disorders Sequencing Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Renal Cystic Disorders Sequencing Panel that also includes the following genes: SALL1 SDCCAG8 HNF1B TFAP2A TSC1 TSC2 CEP41 UMOD VHL ARL6
More info about this panel United States.
ExomePLUS Cystic Disease & Dysplasia/Agenesis Panel
United States.
By Laboratory for Molecular Medicine Partners HealthCare Personalized Medicine ExomePLUS Cystic Disease & Dysplasia/Agenesis that also includes the following genes: BMP4 HNF1B TSC1 TSC2 UMOD WT1 INVS NPHP4 FRAS1 ANKS6
More info about this panel United States.
Polycystic kidney and liver disease modifier panel Panel
United Kingdom.
By Sheffield Diagnostic Genetics Service Sheffield Children's NHS Foundation Trust Polycystic kidney and liver disease modifier panel that also includes the following genes: HNF1B TSC1 TSC2 UMOD DNAJB11 SEC61B SEC61A1 SEC63 ALG8 DZIP1L
More info about this panel United Kingdom.
Renal tubular dysgenesis (sequence analysis of REN gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the REN gene.
More info about this panel Portugal.
Familial juvenile hyperuricemic nephropathy (sequence analysis of REN gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the REN gene.
More info about this panel Portugal.
Familial juvenile hyperuricemic nephropathy (sequence analysis of REN gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the REN gene.
More info about this panel Portugal.
Hyperuricemic nephropathy, familial juvenile, 2 Panel
Germany.
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders
This panel specifically test the REN gene.
More info about this panel Germany.
Test for Renal Tubular Dysgenesis, REN-Related Panel
Germany.
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders
This panel specifically test the REN gene.
More info about this panel Germany.
Renal tubular dysgenesis Panel
Germany.
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Renal tubular dysgenesis that also includes the following genes: AGTR1 REN
More info about this panel Germany.
Benign hyperproreninemia Panel
Germany.
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders
This panel specifically test the REN gene.
More info about this panel Germany.
Congenital Abnormalities of the Kidney and Urinary Tract (CAKUT) Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Congenital Abnormalities of the Kidney and Urinary Tract (CAKUT) Sequencing Panel with CNV Detection that also includes the following genes: ROBO2 SALL1 BMP4 BMP7 SIX1 SIX2 SIX5 SOX11 TBX18 HNF1B
More info about this panel United States.
Autosomal Recessive Renal Tubular Dysgenesis (RTD) via REN Gene Sequencing with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics
This panel specifically test the REN gene.
More info about this panel United States.
Autosomal Recessive Renal Tubular Dysgenesis (RTD) Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Autosomal Recessive Renal Tubular Dysgenesis (RTD) Sequencing Panel with CNV Detection that also includes the following genes: AGTR1 REN
More info about this panel United States.
Renal tubular dysgenesis Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Renal tubular dysgenesis Deletion / Duplication panel that also includes the following genes: AGTR1 REN
More info about this panel United States.
Renal tubular dysgenesis Comprehensive panel Panel
United States.
By Connective Tissue Gene Tests Renal tubular dysgenesis Comprehensive panel that also includes the following genes: AGTR1 REN
More info about this panel United States.
Renal tubular dysgenesis NGS panel Panel
United States.
By Connective Tissue Gene Tests Renal tubular dysgenesis NGS panel that also includes the following genes: AGTR1 REN
More info about this panel United States.
Hyperuricemic nephropathy, familial juvenile Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Hyperuricemic nephropathy, familial juvenile Deletion / Duplication panel that also includes the following genes: UMOD SEC61A1 REN
More info about this panel United States.
Hyperuricemic nephropathy, familial juvenile Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Hyperuricemic nephropathy, familial juvenile Deletion / Duplication panel that also includes the following genes: UMOD SEC61A1 REN
More info about this panel United States.
Hyperuricemic nephropathy, familial juvenile NGS panel Panel
United States.
By Connective Tissue Gene Tests Hyperuricemic nephropathy, familial juvenile NGS panel that also includes the following genes: UMOD SEC61A1 REN
More info about this panel United States.
Familial juvenile hyperuricemic nephropathy type 2 Panel
Germany.
By Institute of Human Genetics Uniklinik RWTH Aachen
This panel specifically test the REN gene.
More info about this panel Germany.
Renal tubular dysgenesis, REN-related Panel
Germany.
By Institute of Human Genetics Uniklinik RWTH Aachen
This panel specifically test the REN gene.
More info about this panel Germany.
Hereditary kidney disorders - different panels Panel
Germany.
By Institute of Human Genetics Uniklinik RWTH Aachen Hereditary kidney disorders - different panels that also includes the following genes: BCS1L ROBO2 CNNM2 CFB SALL1 ATXN10 SCNN1A SCNN1B SCNN1G SDCCAG8
More info about this panel Germany.
Nephrology Endocrinology and Electrolytes - panels Panel
Germany.
By MGZ Medical Genetics Center Nephrology Endocrinology and Electrolytes - panels that also includes the following genes: ROBO2 SALL1 BLK BMP4 BMP7 SIX1 SIX2 SIX5 SLC12A1 SLC12A3
More info about this panel Germany.
Renal tubular dysgenesis Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the REN gene.
More info about this panel Germany.
Renal Tubular Dysgenesis Panel Panel
Germany.
By CeGaT GmbH Renal Tubular Dysgenesis Panel that also includes the following genes: AGTR1 REN
More info about this panel Germany.
REN Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the REN gene.
More info about this panel United States.
Renal Malformation Panel Panel
Finland.
By Blueprint Genetics Renal Malformation Panel that also includes the following genes: ROBO2 SALL1 BMP4 SIX1 SIX5 HNF1B WT1 ACTG2 FREM1 FREM2
More info about this panel Finland.
Comprehensive Hematology Panel Panel
Finland.
By Blueprint Genetics Comprehensive Hematology Panel that also includes the following genes: RHAG RIT1 RPL11 RPL15 RPL35A RPL5 RPS10 RPS19 RPS24 RPS26
More info about this panel Finland.
Comprehensive Metabolism Panel Panel
Finland.
By Blueprint Genetics Comprehensive Metabolism Panel that also includes the following genes: BCS1L CNNM2 RYR1 CNNM4 SCN4A SEC23B SGSH SI SLC40A1 SLC12A3
More info about this panel Finland.
Anemia Panel Panel
Finland.
By Blueprint Genetics Anemia Panel that also includes the following genes: RHAG RPL11 RPL15 RPL35A RPL5 RPS10 RPS19 RPS24 RPS26 RPS29
More info about this panel Finland.
Purine and Pyrimidine Metabolism Disorders Panel Panel
Finland.
By Blueprint Genetics Purine and Pyrimidine Metabolism Disorders Panel that also includes the following genes: TPMT UMOD UMPS XDH GPHN UPB1 NT5C3A MOCOS ADA DHODH
More info about this panel Finland.
Study of Molecular Markers Of Essential Hypertension and Associated Cardiovascular Events (37 genes - 57 genetic variants) Panel
Portugal.
By HeartGenetics, Genetics and Biotechnology, SA Study of Molecular Markers Of Essential Hypertension and Associated Cardiovascular Events (37 genes - 57 genetic variants) that also includes the following genes: SCNN1A SCNN1B SLC12A3 CALCA WNK1 STK39 CLCNKA CLCNKB ADD1 ADRA1A
More info about this panel Portugal.
HYPERURICEMIC NEPHROPATHY, FAMILIAL JUVENILE TYPE2 Panel
Spain.
By Laboratorio de Genetica Clinica SL
This panel specifically test the REN gene.
More info about this panel Spain.
RENAL TUBULAR DYSGENESIS Panel
Spain.
By Laboratorio de Genetica Clinica SL RENAL TUBULAR DYSGENESIS that also includes the following genes: AGTR1 REN
More info about this panel Spain.
CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT (CAKUT) NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT (CAKUT) NGS PANEL that also includes the following genes: ROBO2 SALL1 BMP4 BMP7 SIX1 SIX2 SIX5 HNF1B UMOD UPK3A
More info about this panel Spain.
Familial Juvenile Hyperuricemic Nephropathy Type 2 , Sequencing REN Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the REN gene.
More info about this panel Spain.
Renal Tubular Dysgenesis , Panel Massive Sequencing (NGS) ACE, AGT, AGTR1, REN Genes Panel
Spain.
By Reference Laboratory Genetics Renal Tubular Dysgenesis , Panel Massive Sequencing (NGS) ACE, AGT, AGTR1, REN Genes that also includes the following genes: AGTR1 REN
More info about this panel Spain.
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