VCAN gene related symptoms and diseases
All the information presented here about the VCAN gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to VCAN gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Cataract | Uncommon - Between 30% and 50% cases |
| Vitreoretinopathy | Uncommon - Between 30% and 50% cases |
| Peripheral tractional retinal detachment | Uncommon - Between 30% and 50% cases |
| Erosive vitreoretinopathy | Uncommon - Between 30% and 50% cases |
| Optically empty vitreous | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with VCAN gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Moderate myopia
- Rhegmatogenous retinal detachment
- Vitreous floaters
- Presenile cataracts
- Mild myopia
- Chorioretinal dystrophy
- Exudative vitreoretinopathy
- Retinal pigment epithelial atrophy
And 15 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to VCAN gene
Here you will find a list of rare diseases related to the VCAN. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
WAGNER DISEASE
Alternate names
WAGNER DISEASE Is also known as wagner syndrome, dominant hyaloideoretinal dystrophy of wagner, vitreoretinal degeneration, wagner type, vcan-related vitreoretinopathy
Description
Wagner disease is a rare hereditary vitreoretinopathy characterized by an anomaleous vitreous associated with myopia, cataract, chorioretinal atrophy, and peripheral tractional or rhegmatogenous retinal detachment.
More info about WAGNER DISEASE
SOURCES: ORPHANET
WAGNER VITREORETINOPATHY; WGVRP
Alternate names
WAGNER VITREORETINOPATHY; WGVRP Is also known as erosive vitreoretinopathy, wagner syndrome 1, wagner vitreoretinal degeneration, hyaloideoretinal degeneration of wagner, wgn1, ervr
Description
Wagner vitreoretinopathy is a rare vitreoretinal degeneration inherited as an autosomal dominant trait, first described in a large Swiss pedigree (Wagner, 1938) and subsequently identified in other families. Penetrance in Wagner syndrome is complete, and the disease manifests in childhood or adolescence with a progressive course. Affected individuals usually present with an 'empty' vitreous cavity with fibrillary condensation or avascular strands and veils. Additional features, which are variable and age-dependent, include chorioretinal atrophy with loss of the retinal pigment epithelium (RPE), lattice degeneration of the retina, complicated cataracts, mild myopia, and peripheral traction retinal detachment. Rod and cone electroretinography shows reduced b-wave amplitude and correlates with severe chorioretinal pathology. It is believed that liquefaction of vitreous initiates a degenerative cascade that results in the complex eye phenotype of Wagner syndrome (summary by Kloeckener-Gruissem et al., 2006). Patients with additional ocular features such as progressive nyctalopia (night blindness), visual field constriction, and chorioretinal atrophy, with loss of RPE and choriocapillaries on fluorescein angiography and rod-cone abnormalities on electroretinography, were initially believed to have a distinct clinical entity, which was designated 'erosive vitreoretinopathy' (ERVR). Extraocular abnormalities are not present in patients diagnosed with Wagner or erosive vitreoretinopathy (summary by Mukhopadhyay et al., 2006).
Most common symptoms of WAGNER VITREORETINOPATHY; WGVRP
- Cataract
- Visual impairment
- Myopia
- Optic atrophy
- Blindness
More info about WAGNER VITREORETINOPATHY; WGVRP
SOURCES: OMIM
Search interest in VCAN
Potential gene panels for VCAN gene
Wagner syndrome (sequence analysis of VCAN gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the VCAN gene.
More info about this panel Portugal.
Wagner Syndrome via VCAN Gene Sequencing with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics
This panel specifically test the VCAN gene.
More info about this panel United States.
Comprehensive Vitreoretinopathy Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Comprehensive Vitreoretinopathy Sequencing Panel with CNV Detection that also includes the following genes: ATOH7 CAPN5 RCBTB1 ATP6V0A2 ZNF408 TSPAN12 VCAN CTNNB1 ISPD FZD4
More info about this panel United States.
Stickler Syndrome Sequencing Panel Panel
United States.
By PreventionGenetics PreventionGenetics Stickler Syndrome Sequencing Panel that also includes the following genes: LOXL3 COL11A1 COL11A2 COL9A1 COL9A2 COL9A3 VCAN LRP2
More info about this panel United States.
Comprehensive Inherited Retinal Dystrophies (includes RPGR ORF15) Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Comprehensive Inherited Retinal Dystrophies (includes RPGR ORF15) Sequencing Panel with CNV Detection that also includes the following genes: RGS9 RHO GRK1 RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR
More info about this panel United States.
Stickler syndrome Comprehensive panel Panel
United States.
By Connective Tissue Gene Tests Stickler syndrome Comprehensive panel that also includes the following genes: LOXL3 COL11A1 COL11A2 COL9A1 COL9A2 COL9A3 VCAN
More info about this panel United States.
Vitreoretinopathy Comprehensive panel Panel
United States.
By Connective Tissue Gene Tests Vitreoretinopathy Comprehensive panel that also includes the following genes: RS1 BEST1 CAPN5 ZNF408 TSPAN12 COL11A1 COL11A2 COL18A1 COL9A1 COL9A2
More info about this panel United States.
Vitreoretinopathy Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Vitreoretinopathy Deletion / Duplication panel that also includes the following genes: RS1 BEST1 CAPN5 ZNF408 TSPAN12 COL11A1 COL11A2 COL18A1 COL9A1 COL9A2
More info about this panel United States.
Stickler syndrome Deletion / Duplication panel Panel
United States.
By Connective Tissue Gene Tests Stickler syndrome Deletion / Duplication panel that also includes the following genes: LOXL3 COL11A1 COL11A2 COL9A1 COL9A2 COL9A3 VCAN
More info about this panel United States.
Stickler syndrome NGS panel Panel
United States.
By Connective Tissue Gene Tests Stickler syndrome NGS panel that also includes the following genes: LOXL3 COL11A1 COL11A2 COL9A1 COL9A2 COL9A3 VCAN
More info about this panel United States.
Vitreoretinopathy NGS panel Panel
United States.
By Connective Tissue Gene Tests Vitreoretinopathy NGS panel that also includes the following genes: RS1 BEST1 CAPN5 ZNF408 TSPAN12 COL11A1 COL11A2 COL18A1 COL9A1 COL9A2
More info about this panel United States.
Wagner vitreoretinopathy Deletion / Duplication test Panel
United States.
By Connective Tissue Gene Tests
This panel specifically test the VCAN gene.
More info about this panel United States.
Wagner vitreoretinopathy Sequencing test Panel
United States.
By Connective Tissue Gene Tests
This panel specifically test the VCAN gene.
More info about this panel United States.
Wagner vitreoretinopathy Comprehensive test Panel
United States.
By Connective Tissue Gene Tests
This panel specifically test the VCAN gene.
More info about this panel United States.
Ectopia Lentis Panel
Germany.
By MGZ Medical Genetics Center Ectopia Lentis that also includes the following genes: ADAMTS10 CBS ADAMTS17 ADAMTSL4 COL11A1 COL18A1 VCAN FBN1 ASPH
More info about this panel Germany.
Eye Diseases - panels Panel
Germany.
By MGZ Medical Genetics Center Eye Diseases - panels that also includes the following genes: BFSP1 BFSP2 SALL2 BMP4 BMP7 SHH SIX3 SIX6 FOXL2 SOX2
More info about this panel Germany.
Stickler Syndrome / High Myopia Panel
Germany.
By MGZ Medical Genetics Center Stickler Syndrome / High Myopia that also includes the following genes: P3H2 COL11A1 COL18A1 COL5A1 COL5A2 COL9A1 COL9A2 COL9A3 VCAN FBN1
More info about this panel Germany.
Wagner syndrome Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the VCAN gene.
More info about this panel Germany.
Vitreoretinopathy and Wagner syndrome panel Panel
Germany.
By Centogene AG - the Rare Disease Company Vitreoretinopathy and Wagner syndrome panel that also includes the following genes: TSPAN12 VCAN FZD4 LRP5 NDP
More info about this panel Germany.
Familial Exudative Vitreoretinopathy and Wagner syndrome Panel Panel
Germany.
By CeGaT GmbH Familial Exudative Vitreoretinopathy and Wagner syndrome Panel that also includes the following genes: CAPN5 ZNF408 TSPAN12 VCAN FZD4 LRP5 NDP
More info about this panel Germany.
Single gene testing VCAN Panel
Germany.
By CeGaT GmbH
This panel specifically test the VCAN gene.
More info about this panel Germany.
Test for VCAN-Related Vitreoretinopathy Panel
United Kingdom.
By All Wales Genetics Laboratory Institute of Medical Genetics
This panel specifically test the VCAN gene.
More info about this panel United Kingdom.
Eye diseases comprehensive panel Panel
Estonia.
By Asper Biogene Asper Biogene LLC Eye diseases comprehensive panel that also includes the following genes: RGS9 RHO GRK1 RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR
More info about this panel Estonia.
Vitreoretinopathy Panel
Estonia.
By Asper Biogene Asper Biogene LLC Vitreoretinopathy that also includes the following genes: RS1 BEST1 CAPN5 ZNF408 TSPAN12 COL11A1 COL11A2 COL18A1 COL9A1 COL9A2
More info about this panel Estonia.
Retinal Dystrophy Panel Panel
United States.
By Molecular Vision Laboratory Retinal Dystrophy Panel that also includes the following genes: RGS9 RHO GRK1 RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR
More info about this panel United States.
Vitreoretinopathy panel Panel
United States.
By Molecular Vision Laboratory Vitreoretinopathy panel that also includes the following genes: ATOH7 CAPN5 ZNF408 TSPAN12 COL11A1 COL11A2 COL18A1 COL4A3 COL4A4 COL4A5
More info about this panel United States.
MVL Vision Panel Panel
United States.
By Molecular Vision Laboratory MVL Vision Panel that also includes the following genes: RGS9 RHO GRK1 RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR
More info about this panel United States.
Wagner, Syndrome: VCAN gene mutation analysis Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the VCAN gene.
More info about this panel Spain.
Vitreoretinopathy and Wagner syndrome Panel
Spain.
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases Vitreoretinopathy and Wagner syndrome that also includes the following genes: TSPAN12 VCAN FZD4 LRP5 NDP
More info about this panel Spain.
NGS panel - Stickler syndrome and related disorders Panel
Netherlands.
By Genome Diagnostics VU University Medical Center NGS panel - Stickler syndrome and related disorders that also includes the following genes: SLC26A2 COL11A1 COL11A2 COL9A1 COL9A2 COL9A3 VCAN
More info about this panel Netherlands.
Eye Disorders: Comprehensive Sequencing Panel Panel
United States.
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Eye Disorders: Comprehensive Sequencing Panel that also includes the following genes: RGS9 RHO RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR RS1
More info about this panel United States.
Vitreoretinopathy: Sequencing and Deletion/Duplication Panel Panel
United States.
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Vitreoretinopathy: Sequencing and Deletion/Duplication Panel that also includes the following genes: TSPAN12 COL11A1 COL9A1 VCAN FZD4 KCNJ13 LRP5 NDP
More info about this panel United States.
Retina/Photoreceptor Dystrophy: Sequencing Panel Panel
United States.
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Retina/Photoreceptor Dystrophy: Sequencing Panel that also includes the following genes: RGS9 RHO RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR CNNM4
More info about this panel United States.
Eye Disorders: Deletion/Duplication Panel Panel
United States.
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Eye Disorders: Deletion/Duplication Panel that also includes the following genes: RGS9 RHO RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR RS1
More info about this panel United States.
Eye Disorders NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Eye Disorders NGS Panel that also includes the following genes: RGS9 RHO RLBP1 ROM1 RP1 RP2 RP9 RPE65 RPGR CNNM4
More info about this panel United States.
Vitreoretinopathy and Wagner Syndrome NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Vitreoretinopathy and Wagner Syndrome NGS Panel that also includes the following genes: TSPAN12 VCAN FZD4 LRP5 NDP
More info about this panel United States.
VCAN Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the VCAN gene.
More info about this panel United States.
Marfan Syndrome Panel Panel
Finland.
By Blueprint Genetics Marfan Syndrome Panel that also includes the following genes: BGN SKI TGFB2 TGFB3 TGFBR1 TGFBR2 MED12 ADAMTS10 SLC2A10 CBS
More info about this panel Finland.
Retinal Dystrophy Panel Panel
Finland.
By Blueprint Genetics Retinal Dystrophy Panel that also includes the following genes: RGS9 RHO RLBP1 ROM1 RP1 RP2 RPE65 RPGR RS1 CNNM4
More info about this panel Finland.
Stickler Syndrome Panel Panel
Finland.
By Blueprint Genetics Stickler Syndrome Panel that also includes the following genes: COL11A1 COL11A2 COL9A1 COL9A2 COL9A3 VCAN LRP2
More info about this panel Finland.
Vitreoretinopathy Panel Panel
Finland.
By Blueprint Genetics Vitreoretinopathy Panel that also includes the following genes: RS1 BEST1 ATOH7 CAPN5 P3H2 ZNF408 TSPAN12 COL11A1 COL11A2 COL18A1
More info about this panel Finland.
WAGNER SYNDROME Panel
Spain.
By Laboratorio de Genetica Clinica SL
This panel specifically test the VCAN gene.
More info about this panel Spain.
VITREORETINOPATHY NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL VITREORETINOPATHY NGS PANEL that also includes the following genes: BEST1 CAPN5 P3H2 ZNF408 TSPAN12 VCAN CTNNB1 FZD4 KCNJ13 LRP5
More info about this panel Spain.
Wagner Syndrome , Sequencing VCAN Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the VCAN gene.
More info about this panel Spain.
Wagner Syndrome , Screening Frequent Mutations VCAN Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the VCAN gene.
More info about this panel Spain.
Familial Exudative Vitreoretinopathy and Wagner Syndrome , Panel Massive Sequencing (NGS) 5 Genes Panel
Spain.
By Reference Laboratory Genetics Familial Exudative Vitreoretinopathy and Wagner Syndrome , Panel Massive Sequencing (NGS) 5 Genes that also includes the following genes: TSPAN12 VCAN FZD4 LRP5 NDP
More info about this panel Spain.
VCAN-Related Vitreoretinopathy: gene sequencing Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics
This panel specifically test the VCAN gene.
More info about this panel Canada.
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