1. Mendelian
  2. Rare Diseases
  3. ALZHEIMER DISEASE 2; AD2

Alzheimer Disease 2; Ad2

Table of contents:

Description

A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads. [HPO:probinson]

Genes related to Alzheimer Disease 2; Ad2

  • APOE

View recommended genes panels

Clinical Features

Top most frequent phenotypes and symptoms related to Alzheimer Disease 2; Ad2

  • Hypertension
  • Dementia
  • Diabetes mellitus
  • Stroke
  • Parkinsonism
  • Memory impairment
  • Apraxia
  • Myocardial infarction
  • Alzheimer disease
  • Neurofibrillary tangles

And another 2 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Alternative names

Alzheimer Disease 2; Ad2 Is also known as alzheimer disease associated with apoe4, alzheimer disease 2, late-onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Alzheimer Disease 2; Ad2 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
ADmark® ApoE Genotype Analysis and Interpretation (Symptomatic).

By Athena Diagnostics Inc (United States).

APOE
Specificity
100 %
Genes
100 %
Dementia.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University (United States).

SORL1, TARDBP, VCP, FIG4, OPTN, TREM2, CSF1R, CHMP2B, DCTN1, C9orf72, FUS, ALS2, SETX, GRN, ANG, APOE, APP, MAPT, PRNP, PSEN1 , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
100 %
Apolipoprotein E (APOE) Genotype.

By Molecular Diagnostics Laboratory University of Toledo Medical Center (United States).

APOE
Specificity
100 %
Genes
100 %
APOE.

By Institute for Human Genetics University Clinic Freiburg (Germany).

APOE
Specificity
100 %
Genes
100 %
Alzheimer Disease Risk Factor (APOE).

By GENE Núcleo de Genética Médica de Minas Gerais (Brazil).

APOE
Specificity
100 %
Genes
100 %
Cardiovascular Disease Risk Factor (Apolipoprotein E).

By Sheffield Diagnostic Genetics Service Sheffield Children's NHS Foundation Trust (United Kingdom).

APOE
Specificity
100 %
Genes
100 %
Dyslipidemia NGS panel (29 genes), Sequence & CNV analysis.

By Laboratory of genome diagnostics Academic Medical Center, University of Amsterdam (Netherlands).

SAR1B, SLCO1B1, ABCG5, ABCG8, LMF1, SCARB1, APOA5, LDLRAP1, CETP, PCSK9, MYLIP, STAP1, GPIHBP1, CYP27A1, CYP7A1, ANGPTL3, APOC2, APOC3, APOE, LCAT , (...)

View the complete list with 5 more genes
Specificity
4 %
Genes
100 %
APOE. Genotyping of the alleles E2, E3 and E4.

By Instituto de Medicina Genomica Instituto de Medicina Genomica (Spain).

APOE
Specificity
100 %
Genes
100 %

You can get up to 61 more panels with our dedicated tool

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Sources and references

You can check the following sources for additional information.

OMIM MESH Genetic Syndrome Finder

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like LISSENCEPHALY 1; LIS1 SPASTIC PARAPLEGIA-PAGET DISEASE OF BONE SYNDROME CHROMOSOME 17q11.2 DELETION SYNDROME, 1.4-MB DYSTONIA 25; DYT25 LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 4; FPLD4