Hypertension, Essential

Table of contents:

Description
Related genes
Clinical Features
Incidence and onset information
Alternative Names
Researches and researchers
Gene Panels
Sources and references

Description

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.

Genes related to Hypertension, Essential

ECE1
RGS5
CYP3A5
NOS2
ADD1
GNB3
PTGIS
AGTR1
ATP1B1

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Clinical Features

Top most frequent phenotypes and symptoms related to Hypertension, Essential

Hypertension
Hypertonia
Small for gestational age
Hypotension
Malnutrition
Hyperaldosteronism
Pseudohypoaldosteronism
Large placenta
Elevated systolic blood pressure
Elevated diastolic blood pressure

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Hypertension, Essential Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Hirschsprung disease, cardiac defects, and autonomic dysfunction (sequence analysis of ECE1 gene). By CGC Genetics (Portugal). ECE1 Specificity 100 % Genes 12 %
Hirschsprung Disease (Non-syndromic) Sequencing Panel with CNV Detection. By PreventionGenetics PreventionGenetics (United States). ECE1, EDN3, EDNRB, GDNF, NRTN, RET Specificity 17 % Genes 12 %
Hirschsprung Disease, Cardiac Defects and Autonomic Dysfunction via ECE1 Gene Sequencing with CNV Detection. By PreventionGenetics PreventionGenetics (United States). ECE1 Specificity 100 % Genes 12 %
Central hypoventilation syndrome, congenital. By Centogene AG - the Rare Disease Company (Germany). ECE1 Specificity 100 % Genes 12 %
Hirschsprung disease. By Centogene AG - the Rare Disease Company (Germany). ECE1 Specificity 100 % Genes 12 %
Hirschsprung Disease NGS Panel. By Fulgent Genetics Fulgent Genetics (United States). ECE1, EDN3, EDNRB, GDNF, RET Specificity 20 % Genes 12 %
ECE1. By Fulgent Genetics Fulgent Genetics (United States). ECE1 Specificity 100 % Genes 12 %
Study of Molecular Markers Of Essential Hypertension and Associated Cardiovascular Events (37 genes - 57 genetic variants). By HeartGenetics, Genetics and Biotechnology, SA (Portugal). SCNN1A, SCNN1B, SLC12A3, CALCA, WNK1, STK39, CLCNKA, CLCNKB, ADD1, ADRA1A, ECE1, AGTR1, AGTR2, GNB3, GRK4, HSD11B2, NEDD4L, NOS2, NPPA, NR3C2 , (...) View the complete list with 1 more genes Panel complete gene list SCNN1A, SCNN1B, SLC12A3, CALCA, WNK1, STK39, CLCNKA, CLCNKB, ADD1, ADRA1A, ECE1, AGTR1, AGTR2, GNB3, GRK4, HSD11B2, NEDD4L, NOS2, NPPA, NR3C2, REN Specificity 24 % Genes 56 %

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Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Symptoms Checker

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