Ovarian Cancer

Table of contents:

Description
Related genes
Clinical Features
Incidence and onset information
Alternative Names
Researches and researchers
Gene Panels
Sources and references

Description

Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008).

Genes related to Ovarian Cancer

CDH1
PIK3CA
AKT1
CTNNB1
PRKN
OPCML

View recommended genes panels

Clinical Features

Top most frequent phenotypes and symptoms related to Ovarian Cancer

Neoplasm
Pain
Fatigue
Respiratory distress
Vomiting
Abnormality of metabolism/homeostasis
Constipation
Abdominal pain
Weight loss
Gastroesophageal reflux

And another 16 symptoms. If you need more information about this disease we can help you.

Click here to know more about Mendelian.

Incidence and onset information

— Based on the latest data available OVARIAN CANCER have a estimated prevalence of 30 per 100k worldwide.
— No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Ovarian Cancer Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Hereditary High Risk Breast Cancer Panel. By Baylor Miraca Genetics Laboratories (United States). BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN Specificity 15 % Genes 17 %
Hereditary High Risk Breast Cancer Panel. By Baylor Miraca Genetics Laboratories (United States). BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN Specificity 15 % Genes 17 %
Comprehensive Hereditary Cancer Panel. By Baylor Miraca Genetics Laboratories (United States). RUNX1, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, VHL, WT1, CBL, SUFU, CDC73, CDH1, CDK4, CDKN1C, CDKN2A , (...) View the complete list with 39 more genes Panel complete gene list RUNX1, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, VHL, WT1, CBL, SUFU, CDC73, CDH1, CDK4, CDKN1C, CDKN2A, CEBPA, SBDS, BRIP1, SDHAF2, TMEM127, PALB2, FLCN, ENG, FH, GATA2, ALK, GPC3, APC, SMAD4, MAX, MEN1, MET, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, NF2, ATM, PAX5, PMS1, PMS2, PHOX2B, PRF1, PRKAR1A, BARD1, PTCH1, PTEN, PTPN11, RAD50, RAD51C, RAD51D, RET Specificity 2 % Genes 17 %
Hereditary Colorectal/Gastrointestinal Cancer Panel. By Baylor Miraca Genetics Laboratories (United States). BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDK4, CDKN2A, PALB2, ENG, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, ATM, PMS1, PMS2 , (...) View the complete list with 1 more genes Panel complete gene list BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDK4, CDKN2A, PALB2, ENG, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, ATM, PMS1, PMS2, PTEN Specificity 5 % Genes 17 %
Comprehensive breast and ovarian cancer panel testing (18 genes). By Molecular Genetics Laboratory Centro de Investigaciones Endocrinologicas "Dr. Cesar Bergada" (Argentina). BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, BRIP1, PALB2, MLH1, MSH2, MSH6, MUTYH, ATM, PMS2, PTEN, RAD51C, RAD51D Specificity 6 % Genes 17 %
Comprehensive breast cancer panel testing (10 genes). By Molecular Genetics Laboratory Centro de Investigaciones Endocrinologicas "Dr. Cesar Bergada" (Argentina). BRCA1, BRCA2, STK11, TP53, CDH1, BRIP1, PALB2, ATM, PTEN Specificity 12 % Genes 17 %
Hereditary Diffuse Gastric Cancer. By DNA Diagnostic Laboratory Henry Ford Hospital (United States). CDH1 Specificity 100 % Genes 17 %
CDH1 full gene sequencing analysis. By Clinical Molecular Diagnostic Laboratory City of Hope National Medical Center (United States). CDH1 Specificity 100 % Genes 17 %

You can get up to 390 more panels with our dedicated tool

Learn more

Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Genetic Syndrome Finder

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like SHORT-RIB THORACIC DYSPLASIA 14 WITH POLYDACTYLY; SRTD14 PROLIFERATIVE VASCULOPATHY AND HYDRANENCEPHALY-HYDROCEPHALY SYNDROME; PVHH PROTEUS-LIKE SYNDROME PROLONGED ELECTRORETINAL RESPONSE SUPPRESSION; PERRS SPONDYLOENCHONDRODYSPLASIA SPONDYLOCOSTAL DYSOSTOSIS 5; SCDO5 SECKEL SYNDROME 5; SCKL5