1. Mendelian
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  3. SPONDYLOARTHROPATHY, SUSCEPTIBILITY TO, 1; SPDA1

Spondyloarthropathy, Susceptibility To, 1; Spda1

Table of contents:

Description

Spondyloarthropathy (SpA), one of the commonest chronic rheumatic diseases, includes a spectrum of related disorders comprising the prototype ankylosing spondylitis (AS), a subset of psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathy (Miceli-Richard et al., 2004). These phenotypes are difficult to differentiate because they may occur simultaneously or sequentially in the same patient. Studies have suggested that a predominant shared component, including HLA-B27, predisposes to all phenotypic subsets, and that these subsets should be considered as various phenotypic expressions of the same disease (Said-Nahal et al., 2000, Said-Nahal et al., 2001).Braun and Sieper (2007) provided a detailed review of ankylosing spondylitis, including clinical features, pathogenesis, and management. Genetic Heterogeneity of Susceptibility to SpondyloarthropathyAdditional susceptibility loci for spondyloarthropathy have been identified on chromosome 9q31-q34 (SPDA2 ) and chromosome 2q36 (SPDA3 ).

Genes related to Spondyloarthropathy, Susceptibility To, 1; Spda1

  • HLA-B

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Clinical Features

Top most frequent phenotypes and symptoms related to Spondyloarthropathy, Susceptibility To, 1; Spda1

  • Pain
  • Kyphosis
  • Arrhythmia
  • Photophobia
  • Arthritis
  • Aortic regurgitation
  • Back pain
  • Psoriasiform dermatitis
  • Inflammation of the large intestine
  • Uveitis

And another 7 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Alternative names

Spondyloarthropathy, Susceptibility To, 1; Spda1 Is also known as ankylosing spondylitis, susceptibility to, marie-strumpell spondylitis, bechterew syndrome.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Genetic Syndrome Finder

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